It'd probably work quite well - it'd just be an interstellar version of TS
Yes. My thought was I'd dial down the bio- and nanotech, but the THS solar system seems well fleshed, the events timeline seems compatible (if less apocalyptic than Twilight) and there are a number of readymade vehicles and tech I like. Also the flavor is less merc combat, more mysterious intrigue.
I would agree with the nanotech. The biotech - well, that only doesn't fly on Earth, and less so on Tirane. The Tirane-ans (what IS their plural?) are going along with it to keep ties with Earth.
Most of the colonies would keep the biotech, at least "safe" biotech, simply as a matter of survival.